Factors involved in immunization program for swine influenza
Identifieur interne : 000204 ( 1957/Analysis ); précédent : 000203; suivant : 000205Factors involved in immunization program for swine influenza
Auteurs : Goronwy O. Broun Sr. [États-Unis] ; Dennis O'Connor [États-Unis] ; Rose Rita Schmidt [États-Unis] ; Barbara Puder [États-Unis]Source :
- The American Journal of Medicine [ 0002-9343 ] ; 1976.
English descriptors
- Teeft :
- American journal, Antibody levels, Arch intern, Bacterial infection, Black women, Cent increase, Considerable percentage, December, Different ages, Entire group, Epidemic strain, Fatal cases, Great pandemic, Health progress, High mortality, High percentage, High risk, Hswlnl, Hswlnl strain, Immunization, Immunization program, Immunologic protection, Infection, Influenza, Influenza antibodies, Influenza infection, Influenza infections, Influenza virus, Influenza virus strain, Louis university hospital, Louis university hospital population, Maternal antibodies, Medicine volume, Metropolitan life insurance, Mortality statistics, Nationwide program, Original antigenic, Other diseases, Outbreak, Pandemic, Possible protection, Pregnant women, Prevalent influenza virus strains, Prevalent strains, Puerperal, Puerperal septicemia, Puerperal state, Puerperal women, Serologic studies, Serum pools, Serum specimens, Special consideration, Swine, Swine antibodies, Swine influenza, Swine influenza virus, Swine vaccine, Swine virus, Titer, Titer number, Tract infections, Upper graph, Vaccination, Vaccine, Valvular heart disease, Various population groups, Virus strain, White women, Year period.
Abstract
Abstract: The decision to undertake a nationwide program of vaccination against swine influenza requires assessment of the status of immunity of those in various age groups in our population against this agent. Pools of serum were collected from persons born in the years from 1889 to 1943; they were tested for hemagglutinin inhibiting (HI) antibody against the HSW1N1 influenza virus strains isolated in 1931 and 1976. The titers secured serve as an indication of the average level of immunity of those of different ages. Persons less than 43 years of age are found to be without antibody protection. The need for vaccination of people in different age groups based on mortality statistics of previous epidemics is evaluated. It is realized that no epidemic may occur and that a reduced virulence of the viral agent and use of antibiotics may reduce the death rate if the infection recurs. The extraordinary high mortality in 1918 in people between 15 and 44 years of age deserves recognition together with the fact that those in the same age group are now without protection. The fact that women of childbearing age fall into this group deserves special consideration in view of increased mortality in puerperal women observed in the pandemics of 1918 and 1957. The degree of protection afforded the newborn by transplacental transmission of maternal antibodies is discussed. The need of increasing the level of immunity in those who have varying titers of HI antibodies is considered in relation to the prevalence of cardiopulmonary complications and other chronic diseases in older subjects.
Url:
DOI: 10.1016/0002-9343(76)90416-2
Affiliations:
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Pools of serum were collected from persons born in the years from 1889 to 1943; they were tested for hemagglutinin inhibiting (HI) antibody against the HSW1N1 influenza virus strains isolated in 1931 and 1976. The titers secured serve as an indication of the average level of immunity of those of different ages. Persons less than 43 years of age are found to be without antibody protection. The need for vaccination of people in different age groups based on mortality statistics of previous epidemics is evaluated. It is realized that no epidemic may occur and that a reduced virulence of the viral agent and use of antibiotics may reduce the death rate if the infection recurs. The extraordinary high mortality in 1918 in people between 15 and 44 years of age deserves recognition together with the fact that those in the same age group are now without protection. The fact that women of childbearing age fall into this group deserves special consideration in view of increased mortality in puerperal women observed in the pandemics of 1918 and 1957. The degree of protection afforded the newborn by transplacental transmission of maternal antibodies is discussed. The need of increasing the level of immunity in those who have varying titers of HI antibodies is considered in relation to the prevalence of cardiopulmonary complications and other chronic diseases in older subjects.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Broun Sr, Goronwy O" sort="Broun Sr, Goronwy O" uniqKey="Broun Sr G" first="Goronwy O." last="Broun Sr.">Goronwy O. Broun Sr.</name></noRegion><name sortKey="O Connor, Dennis" sort="O Connor, Dennis" uniqKey="O Connor D" first="Dennis" last="O'Connor">Dennis O'Connor</name><name sortKey="Puder, Barbara" sort="Puder, Barbara" uniqKey="Puder B" first="Barbara" last="Puder">Barbara Puder</name><name sortKey="Schmidt, Rose Rita" sort="Schmidt, Rose Rita" uniqKey="Schmidt R" first="Rose Rita" last="Schmidt">Rose Rita Schmidt</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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